The typical symptoms of Qi stagnation are distension, oppression and swelling. Now let's look at the four patterns commonly treated with Ge Xia Zhu Yu Tang. Down-regulating the expressions of the MMP9 can attenuate CCl4-induced liver fibrosis in rats (Peng et al., 2010). The percentages of collagen fiber deposits were counted in 5 randomly selected fields of each stained section using Imagepro-plus 6. In the SwissTargetPrediction database, the probability value of potential target proteins ≥0. Citation: Cao X, Liang Y, Liu R, Zao X, Zhang J, Chen G, Liu R, Chen H, He Y, Zhang J and Ye Y (2022) Uncovering the Pharmacological Mechanisms of Gexia-Zhuyu Formula (GXZY) in Treating Liver Cirrhosis by an Integrative Pharmacology Strategy. Lubricates the Intestines. Tao Ren is a king ingredient in Ge Xia Zhu Yu Tang. Identification and PPI Network Construction of OGEs. The Stomach is a so-called "Fu" Organ. Guo Qi Yin is 50% similar to Ge Xia Zhu Yu Tang. T330203024, Neimenggu, China; 9g), and Faeces Trogopterori (Wulingzhi in Chinese, No.
The studies have shown that inhibition of HBV and intrahepatic inflammation can delay or even reverse the progression of cirrhosis. Blood Stagnation - also often referred to as "Blood Stasis" - is where the Blood flow is heavily restricted in all or parts of the body. This product should be used only as directed on the label. The herbal formula "ge xia zhu yu wan", 隔下逐於丸, which in english is "drive out blood stasis below the diaphragm decoction", is categorized within the "invigorate the blood" functional grouping and within the "invigorate the blood and dispel blood stasis" sub-category. As such Ge Xia Zhu Yu Tang is used by TCM practitioners to treat four different patterns which we describe below.
By clicking "Accept", you agree to our website's cookie use as described in our Cookie Policy. Zhang, Y., Wu, X., Wang, X., Zeng, Y., Liao, Y., Zhang, R., et al. Tea and Instant Beverages. Fraxinus Rhynchophylla Ethanol Extract Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in Rats via Down-Regulating the Expressions of uPA, MMP-2, MMP-9 and TIMP-1. The HE pathological sections of rats showed that the hepatocytes in the model group were uneven in size, ballooning degeneration and necrosis, increased nucleocytoplasmic ratio, and the hepatic cord was swollen and distorted. At the end of the eighth week, the rats in the model group had lower body weight than the control group, and the liver weight and liver index were not statistically significant between the two groups (Figure 4A). The primary antibodies of immunofluorescence staining were rabbit anti-alpha Smooth Muscle Actin (ab124964, Abcam, UK) and anti-CD68 (ab955, Abcam, UK). Packaging: 100 g/bt. As for serological liver function indexes, compared with the control group, the ALT, AST, and ALP indexes in the blood of the model group at the end of the eighth were higher (Figure 4C). With Yan Hu Suo, treats everything from Liver Qi Stagnation to Deep Blood Stasis with pain anywhere in the body including stabbing chest pain, distending pain in the breast, Cold pain in the epigastrium, pain due to bulging disorder in the lower body and dysmenorrhea. Stasis include: Fixed, severe, and/or. Chuan Xiong Gan Cao regulates and harmonizes all the other. Representations Herbal products are food supplements. The Effect of Gexia Zhuyu Tang.
3-4 capsules 3 times a day for an average adult (18-60 years of age, approximately 150 lbs). The Mechanism of TiaoGanYiPi Formula for Treating Chronic Hepatitis B by Network Pharmacology and Molecular Docking Verification. Actions: Calms pain. The dosage of intragastric administration in rats is based on the clinical equivalent dose, which is basically consistent with the previous studies of the same type (Chen et al., 2012).
Blood stasis Yes No. With Tao Ren and Hong Hua, for amenorrhea, pain, swelling and other symptoms associated with Blood Stasis. Externally visible engorged. Ingredients: Peach kernel (tao ren), Carthamus flower (hong hua), Cnidium root (chuan xiong), Tang-kuei root (dang gui), Pteropus (wu ling zhi), Moutan bark (mu dan pi), Red peony root (chi shao), Lindera root (wu yao), Corydalis (yan hu suo), Cyperus root (xiang fu zi), Chih-ko fruit (zhi ke), Chinese licorice root (gan cao). All authors confirmed the final manuscript. Wu Ling Zhi 6 g, - Dang Gui 9 g, - Chuan Xiong 6 g, - Tao Ren 9 g, - Dan Pi 6 g, - Chi Shao 6 g, - Wu Yao 6 g, - Xuan Hu Suo 3 g, - Gan Cao 9 g, - Xiang Fu 4. The overlapped genes (OGEs) were the intersection of the GXZY compound-putative targets and LC disease targets.
No use, distribution or reproduction is permitted which does not comply with these terms. Hui, T., Bai, G., and Liu, F. (2016). Dose should be determined by the practitioner on a case by case basis. Finally, Etsy members should be aware that third-party payment processors, such as PayPal, may independently monitor transactions for sanctions compliance and may block transactions as part of their own compliance programs. For menstrual and lower abdominal pain.
1007/s12072-020-10097-z. Select items to put in your cart. 每日3次,每次2片,飯後15分鐘溫開水送服。. The reverse transcription of total RNA to cDNA was performed with qPCR RT Master Mix kit (TOYOBO, JAN). My patient does present the signs and symptoms of: Qi stagnation Yes No.
Disperses Blood stasis. If you create a custom formula based on the ingredient, they can be easily included. Yue, S. J., Xin, L. T., Fan, Y. C., Li, S. J., Tang, Y. P., Duan, J. Wullaert, A., Heyninck, K., and Beyaert, R. Mechanisms of Crosstalk between TNF-Induced NF-kappaB and JNK Activation in Hepatocytes. Prescription medication or other supplements. Cao, Q., Mak, K. M., and Lieber, C. S. (2006). All Rights Reserved. The purple circles represent key target genes. Macules on the tongue. Copyright © 2022 Cao, Liang, Liu, Zao, Zhang, Chen, Liu, Chen, He, Zhang and Ye. We use cookies to improve user experience and analyze website traffic. Pulse type(s): Choppy (Se), Firm (Lao), Wiry (Xian). Ingredients in the formula. Liver cirrhosis (LC) is a fibrotic lesion of liver tissue caused by the repeated progression of chronic hepatitis.
Liver cirrhosis (LC) develops from liver fibrosis (LF), and LF is a pathological process of collagen-based extracellular matrix (ECM) deposition in the liver (Tsuchida and Friedman, 2017; Kisseleva and Brenner, 2021). Or Paeonia veitchii Lynch) (Tan et al., 2020), Linderae Radix [the dried root of Lindera aggregata (Sims) Kos-term. ] One month after GXZY treatment, collagen fiber deposition in liver tissue decreased (Figure 6B), and the difference was statistically significant (Figure 6D). Promotes the movement of Qi, alleviates pain by warming and dispersing - flank, chest, epigastric, abdominal pain, hernia, menstrual pains due to cold constraint and qi stagnation. To explore the pharmacological mechanisms of Gexia-Zhuyu formula (GXZY) in liver cirrhosis (LC) treatment. The process of this study was shown in Figure 1.
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